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Seth Rogen on Animated Alzheimer’s Movie ‘Tangles,’ Casting Madonna in ‘The Studio’ and Recreating the Venice Film Festival for Season 2: ‘It Is Crazy’

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May 14, 2026 1:45pm PT Seth Rogen on Animated Alzheimer’s Movie ‘Tangles,’ Casting Madonna in ‘The Studio’ and Recreating the Venice Film Festival for Season 2: ‘It Is Crazy’

Producer Lauren Miller Rogen and director Leah Nelson on adapting Sarah Leavitt's graphic novel for the screen.

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Brent Lang

Executive Editor

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Seth Rogen at the "Good Fortune" Beyond Fest screening held at The Egyptian Theatre on October 06, 2025 in Los Angeles, California.
Chad Salvador/Variety

Tangles,” a new black-and-white animated film about a 20-something illustrator named Sarah who is dealing with her mother’s Alzheimer’s disease, was all too real for its producers, Seth Rogen and Lauren Miller Rogen. The couple started dating more than two decades ago, as Miller Rogen’s mother, Adele, was showing the first signs of the illness she would suffer from for the final 16 years of her life.

“There were so many similarities between my family and Sarah’s family,” Miller Rogen says as she sits in a suite at the Majestic Hotel the day before the film debuts at Cannes. “Our moms were both teachers who were diagnosed in their early 50s. I related to the denial, fear and sense of aloneness that can come with a dementia diagnosis.”

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