Early fibrotic niches establish tumour-permissive microenvironments

Nature, Published online: 22 April 2026; doi:10.1038/s41586-026-10399-6

Pathologic transformation in KrasG12D-mutant alveolar type II cells initiates a tumour-permissive niche by orchestrating epithelial, stromal and immune reprogramming through amphiregulin–EGFR signalling, creating a self-sustaining circuit critical for lung tumour initiation and progression.